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Infectious mononucleosis

EFO Endpoint Browser PheWeb

AB1_EBV

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — B27
  • Hospital discharge: ICD-10 — B27
  • Hospital discharge: ICD-9 — 07[5]
  • Hospital discharge: ICD-8 — 07[5]
  • Cause of death: ICD-10 — B27
  • Cause of death: ICD-9 — 07[5]
  • Cause of death: ICD-8 — 07[5]

3 out of 7 registries used, show all original rules.

3546

4. Check minimum number of events

None

3546

5. Include endpoints

None

3546

6. Filter based on genotype QC (FinnGen only)

3439

Control definitions (FinnGen only)

Control exclude AB1_OTHER_VIRAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF10

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 47049 23385 23582
Only index persons 45510 22770 22740
Unadjusted period prevalence (%)
Whole population 0.66 0.67 0.66
Only index persons 0.85 0.84 0.87
Median age at first event (years)
Whole population 17.86 17.23 18.46
Only index persons 17.91 17.29 18.54

-FinnGen-

Key figures

All Female Male
Number of individuals 3439 2218 1221
Unadjusted period prevalence (%) 0.78 0.87 0.61
Median age at first event (years) 18.56 17.92 19.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_EBV and mortality.

Females

Parameter HR [95% CI] p-value
AB1_EBV 1.492 [1.12, 1.99] 0.006
Birth year 1.0 [0.99, 1.01] 0.947

During the follow-up period (1.1.1998 — 31.12.2019), 118 out of 16191 females with AB1_EBV died.

Males

Parameter HR [95% CI] p-value
AB1_EBV 1.411 [1.2, 1.65] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 14786 males with AB1_EBV died.

Mortality risk

Mortality risk for people of age

years, who have AB1_EBV.

N-year risk Females Males
1 0.208% 0.257%
5 1.039% 1.587%
10 2.769% 4.122%
15 5.219% 7.827%
20 8.95% 12.79%

Relationships between endpoints

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Index endpoint: AB1_EBV – Infectious mononucleosis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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