No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
150 |
4. Check minimum number of eventsNone |
150 |
5. Include endpointsNone |
150 |
6. Filter based on genotype QC (FinnGen only) |
141 |
Control definitions (FinnGen only)
Control exclude
AB1_VIRAL_HEPATITIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
B15-B19
Name in latin
Hepatitis A acuta
Similar endpoints
↥List of similar endpoints to
Acute hepatitis A
based on the number of shared cases.
Similar with more cases:
- Acute hepatitis A
- Viral hepatitis, IBD co-morbidity
- Viral hepatitis
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1602 | 688 | 896 |
| Only index persons | 1328 | 598 | 730 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 36.85 | 37.94 | 35.93 |
| Only index persons | 34.38 | 35.37 | 33.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 141 | 72 | 69 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 39.55 | 39.51 | 39.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint AB1_HEPATITIS_A and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_HEPATITIS_A | 2.036 [1.4, 2.96] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.506 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 336 females with AB1_HEPATITIS_A died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_HEPATITIS_A | 3.07 [2.26, 4.18] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 473 males with AB1_HEPATITIS_A died.
Mortality risk
Mortality risk for people of age
years, who have AB1_HEPATITIS_A.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.231% | 0.453% |
| 5 | 1.239% | 3.157% |
| 10 | 3.161% | 7.868% |
| 15 | 6.288% | 14.48% |
| 20 | 11.069% | 23.486% |
Relationships between endpoints
↥Index endpoint: AB1_HEPATITIS_A – Acute hepatitis A
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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