No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2779 |
4. Check minimum number of eventsNone |
2779 |
5. Include endpointsNone |
2779 |
6. Filter based on genotype QC (FinnGen only) |
2659 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF10
Similar endpoints
↥List of similar endpoints to
Lyme disease
based on the number of shared cases.
Similar with more cases:
- Spirochaetal infections, other/unspecified
- Other spirochaetal diseases
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20068 | 10963 | 9048 |
| Only index persons | 18434 | 10171 | 8263 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | 0.31 | 0.25 |
| Only index persons | 0.35 | 0.37 | 0.32 |
| Median age at first event (years) | |||
| Whole population | 52.90 | 53.58 | 52.09 |
| Only index persons | 54.33 | 54.85 | 53.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2659 | 1597 | 1062 |
| Unadjusted period prevalence (%) | 0.59 | 0.63 | 0.53 |
| Median age at first event (years) | 59.18 | 57.38 | 61.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AB1_LYME and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_LYME | 0.785 [0.69, 0.9] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.585 |
During the follow-up period (1.1.1998 — 31.12.2019), 510 out of 8614 females with AB1_LYME died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_LYME | 0.832 [0.72, 0.97] | 0.016 |
| Birth year | 0.982 [0.97, 0.99] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 590 out of 7154 males with AB1_LYME died.
Mortality risk
Mortality risk for people of age
years, who have AB1_LYME.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.146% |
| 5 | 0.51% | 0.768% |
| 10 | 1.295% | 1.919% |
| 15 | 2.546% | 3.763% |
| 20 | 4.477% | 6.672% |
Relationships between endpoints
↥Index endpoint: AB1_LYME – Lyme disease
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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