tabes dorsalis: A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.
Infections with a predominantly sexual mode of transmission
DOID EFO Endpoint Browser PheWeb
AB1_SEXUAL_TRANSMISSION
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
14024 |
6. Filter based on genotype QC (FinnGen only) |
13366 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Infections with a predominantly sexual mode of transmission
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 123298 | 78020 | 44342 |
| Only index persons | 117330 | 75050 | 42280 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.87 | 2.23 | 1.24 |
| Only index persons | 2.35 | 2.76 | 1.61 |
| Median age at first event (years) | |||
| Whole population | 26.14 | 25.54 | 27.09 |
| Only index persons | 25.93 | 25.40 | 26.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 13366 | 9896 | 3470 |
| Unadjusted period prevalence (%) | 3.33 | 3.89 | 1.74 |
| Median age at first event (years) | 27.90 | 26.59 | 31.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AB1_SEXUAL_TRANSMISSION and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_SEXUAL_TRANSMISSION | 1.405 [1.25, 1.57] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.564 |
During the follow-up period (1.1.1998 — 31.12.2019), 1846 out of 56798 females with AB1_SEXUAL_TRANSMISSION died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_SEXUAL_TRANSMISSION | 1.37 [1.23, 1.53] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1639 out of 35162 males with AB1_SEXUAL_TRANSMISSION died.
Mortality risk
Mortality risk for people of age
years, who have AB1_SEXUAL_TRANSMISSION.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.172% | 0.261% |
| 5 | 0.918% | 1.542% |
| 10 | 2.386% | 3.806% |
| 15 | 4.36% | 7.169% |
| 20 | 7.621% | 11.992% |
Relationships between endpoints
↥Index endpoint: AB1_SEXUAL_TRANSMISSION – Infections with a predominantly sexual mode of transmission
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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