≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Shigellosis

EFO Endpoint Browser PheWeb

AB1_SHIGELLOSIS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A03
  • Hospital discharge: ICD-9 — 004.
  • Hospital discharge: ICD-8 — 004[0]
  • Cause of death: ICD-10 — A03
  • Cause of death: ICD-9 — 004.
  • Cause of death: ICD-8 — 004[0]

2 out of 7 registries used, show all original rules.

109

4. Check minimum number of events

None

109

5. Include endpoints

None

109

6. Filter based on genotype QC (FinnGen only)

101

Control definitions (FinnGen only)

Control exclude AB1_INTESTINAL_INFECTIONS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 973 504 461
Only index persons 826 445 381
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 39.41 39.06 39.80
Only index persons 36.35 36.63 36.02

-FinnGen-

Key figures

All Female Male
Number of individuals 101 55 46
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 42.67 38.77 47.33

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_SHIGELLOSIS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_SHIGELLOSIS 1.403 [0.97, 2.03] 0.074
Birth year 0.997 [0.99, 1.01] 0.426

During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 381 females with AB1_SHIGELLOSIS died.

Males

Parameter HR [95% CI] p-value
AB1_SHIGELLOSIS 1.969 [1.19, 3.26] 0.008
Birth year 0.99 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 341 males with AB1_SHIGELLOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_SHIGELLOSIS.

N-year risk Females Males
1 0.135% 0.421%
5 0.893% 2.237%
10 2.16% 5.996%
15 4.042% 11.162%
20 6.91% 18.953%

Relationships between endpoints

↥

Index endpoint: AB1_SHIGELLOSIS – Shigellosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data