No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
136285 |
6. Filter based on genotype QC (FinnGen only) |
131176 |
Control definitions (FinnGen only)
Control exclude
NEURO_COMORBIDITIES
Extra metadata
First used in FinnGen datafreeze
DF2
Depression medications
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1301037 | 797631 | 495459 |
| Only index persons | 1186033 | 738521 | 447512 |
| Unadjusted period prevalence (%) | |||
| Whole population | 19.33 | 22.85 | 13.84 |
| Only index persons | 23.35 | 27.15 | 17.08 |
| Median age at first event (years) | |||
| Whole population | 45.17 | 45.51 | 44.51 |
| Only index persons | 43.34 | 43.69 | 42.76 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 131176 | 85811 | 45365 |
| Unadjusted period prevalence (%) | 29.93 | 33.70 | 22.78 |
| Median age at first event (years) | 44.50 | 42.24 | 48.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ANTIDEPRESSANTS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ANTIDEPRESSANTS | 1.488 [1.39, 1.6] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 103249 out of 611724 females with ANTIDEPRESSANTS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ANTIDEPRESSANTS | 1.798 [1.66, 1.95] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 79482 out of 387224 males with ANTIDEPRESSANTS died.
Mortality risk
Mortality risk for people of age
years, who have ANTIDEPRESSANTS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.079% | 0.249% |
| 5 | 0.594% | 1.465% |
| 10 | 1.431% | 3.877% |
| 15 | 2.817% | 7.036% |
| 20 | 5.127% | 11.528% |
Relationships between endpoints
↥Index endpoint: ANTIDEPRESSANTS – Depression medications
GWS hits: 35
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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