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Malignant neoplasm of biliary tract and gallbladder

Endpoint Browser PheWeb

C3_BILIARY_GALLBLADDER_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C22, C23&, C24
  • Cause of death: ICD-9 — 155|156
  • Cause of death: ICD-8 — 155|156
  • Cancer registry: Topography ICD-O-3 — C2[2-4]
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Similar endpoints

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List of similar endpoints to Malignant neoplasm of biliary tract and gallbladder based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 24302 11220 12465
Only index persons 11082 4778 6304
Unadjusted period prevalence (%)
Whole population 0.34 0.32 0.35
Only index persons 0.21 0.18 0.24
Median age at first event (years)
Whole population 71.90 73.57 70.56
Only index persons 73.54 75.93 71.72

-FinnGen-

Key figures

All Female Male
Number of individuals 1464 416 1048
Unadjusted period prevalence (%) 0.42 0.16 0.53
Median age at first event (years) 72.32 71.38 72.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_BILIARY_GALLBLADDER_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_BILIARY_GALLBLADDER_EXALLC 19.525 [13.98, 27.27] < 0.001
Birth year 0.993 [0.98, 1.0] 0.078

During the follow-up period (1.1.1998 — 31.12.2019), 4146 out of 4790 females with C3_BILIARY_GALLBLADDER_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_BILIARY_GALLBLADDER_EXALLC 15.652 [11.34, 21.62] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 4882 out of 5800 males with C3_BILIARY_GALLBLADDER_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_BILIARY_GALLBLADDER_EXALLC.

N-year risk Females Males
1 1.786% 2.121%
5 8.306% 12.886%
10 20.988% 30.296%
15 35.809% 51.11%
20 56.005% 71.309%

Relationships between endpoints

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Index endpoint: C3_BILIARY_GALLBLADDER_EXALLC – Malignant neoplasm of biliary tract and gallbladder

GWS hits: 4

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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