No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF8
Myelodysplastic syndrome
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3250 | 1504 | 1679 |
| Only index persons | 1987 | 930 | 1057 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.04 | 0.05 |
| Only index persons | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 79.47 | 81.26 | 77.93 |
| Only index persons | 79.50 | 81.45 | 77.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 261 | 91 | 170 |
| Unadjusted period prevalence (%) | 0.07 | 0.04 | 0.09 |
| Median age at first event (years) | 76.35 | 76.78 | 76.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint C3_MYELODYSP_SYNDR_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_MYELODYSP_SYNDR_EXALLC | 5.069 [3.42, 7.52] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.271 |
During the follow-up period (1.1.1998 — 31.12.2019), 557 out of 702 females with C3_MYELODYSP_SYNDR_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_MYELODYSP_SYNDR_EXALLC | 6.966 [4.17, 11.64] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 650 out of 830 males with C3_MYELODYSP_SYNDR_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_MYELODYSP_SYNDR_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.519% | 1.408% |
| 5 | 3.398% | 7.854% |
| 10 | 7.487% | 19.042% |
| 15 | 13.795% | 32.258% |
| 20 | 22.129% | 49.746% |
Relationships between endpoints
↥Index endpoint: C3_MYELODYSP_SYNDR_EXALLC – Myelodysplastic syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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