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Malignant neoplasm of parotid gland

Endpoint Browser PheWeb

C3_PAROTIDGLAND_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C07
  • Cause of death: ICD-9 — 1420
  • Cause of death: ICD-8 — 1420
  • Cancer registry: Topography ICD-O-3 — C07
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2050 1026 991
Only index persons 1359 731 628
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 62.77 63.65 61.70
Only index persons 61.65 62.03 61.20

-FinnGen-

Key figures

All Female Male
Number of individuals 239 116 123
Unadjusted period prevalence (%) 0.05 0.05 0.06
Median age at first event (years) 62.06 59.60 64.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_PAROTIDGLAND_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_PAROTIDGLAND_EXALLC 2.194 [1.68, 2.86] < 0.001
Birth year 0.997 [0.98, 1.01] 0.633

During the follow-up period (1.1.1998 — 31.12.2019), 221 out of 616 females with C3_PAROTIDGLAND_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_PAROTIDGLAND_EXALLC 2.515 [1.88, 3.37] < 0.001
Birth year 0.993 [0.98, 1.0] 0.179

During the follow-up period (1.1.1998 — 31.12.2019), 251 out of 568 males with C3_PAROTIDGLAND_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_PAROTIDGLAND_EXALLC.

N-year risk Females Males
1 0.22% 0.508%
5 1.346% 3.053%
10 3.443% 8.707%
15 6.808% 15.943%
20 11.325% 26.163%

Relationships between endpoints

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Index endpoint: C3_PAROTIDGLAND_EXALLC – Malignant neoplasm of parotid gland

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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