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Malignant neoplasm of stomach

Endpoint Browser PheWeb

C3_STOMACH_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C16
  • Cause of death: ICD-9 — 151
  • Cause of death: ICD-8 — 151
  • Cancer registry: Topography ICD-O-3 — C16
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Similar endpoints

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List of similar endpoints to Malignant neoplasm of stomach based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 33978 13403 19457
Only index persons 11026 4927 6099
Unadjusted period prevalence (%)
Whole population 0.50 0.38 0.54
Only index persons 0.21 0.18 0.23
Median age at first event (years)
Whole population 68.23 69.61 67.43
Only index persons 69.51 70.16 68.98

-FinnGen-

Key figures

All Female Male
Number of individuals 1741 555 1186
Unadjusted period prevalence (%) 0.48 0.22 0.60
Median age at first event (years) 67.88 65.42 69.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_STOMACH_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_STOMACH_EXALLC 6.767 [5.79, 7.9] < 0.001
Birth year 0.995 [0.99, 1.0] 0.188

During the follow-up period (1.1.1998 — 31.12.2019), 4163 out of 5529 females with C3_STOMACH_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_STOMACH_EXALLC 6.742 [5.65, 8.05] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 5786 out of 7271 males with C3_STOMACH_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_STOMACH_EXALLC.

N-year risk Females Males
1 0.725% 1.277%
5 3.629% 7.406%
10 8.509% 18.002%
15 15.718% 30.83%
20 27.617% 46.888%

Relationships between endpoints

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Index endpoint: C3_STOMACH_EXALLC – Malignant neoplasm of stomach

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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