No definition available.
Cirrhosis, broad definition used in the article https://doi.org/10.1101/594523
CIRRHOSIS_BROAD
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
5017 |
6. Filter based on genotype QC (FinnGen only) |
4869 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF3
Cirrhosis, broad definition used in the article https://doi.org/10.1101/594523
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 82343 | 22329 | 58113 |
| Only index persons | 48746 | 14732 | 34014 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.37 | 0.64 | 1.62 |
| Only index persons | 1.07 | 0.54 | 1.30 |
| Median age at first event (years) | |||
| Whole population | 57.17 | 59.00 | 56.47 |
| Only index persons | 58.89 | 60.06 | 58.39 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4869 | 1541 | 3328 |
| Unadjusted period prevalence (%) | 1.33 | 0.61 | 1.67 |
| Median age at first event (years) | 60.21 | 59.05 | 60.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CIRRHOSIS_BROAD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CIRRHOSIS_BROAD | 8.13 [7.25, 9.12] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 6151 out of 11927 females with CIRRHOSIS_BROAD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CIRRHOSIS_BROAD | 8.378 [7.44, 9.44] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 14589 out of 24815 males with CIRRHOSIS_BROAD died.
Mortality risk
Mortality risk for people of age
years, who have CIRRHOSIS_BROAD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.801% | 1.206% |
| 5 | 4.445% | 8.315% |
| 10 | 9.334% | 19.603% |
| 15 | 17.842% | 34.865% |
| 20 | 30.193% | 53.154% |
Relationships between endpoints
↥Index endpoint: CIRRHOSIS_BROAD – Cirrhosis, broad definition used in the article https://doi.org/10.1101/594523
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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