This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Disorder of amino-acid metabolism, other/unspecified
E4_AMINONAS
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
39 |
4. Check minimum number of eventsNone |
39 |
5. Include endpointsNone |
39 |
6. Filter based on genotype QC (FinnGen only) |
38 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Disorder of amino-acid metabolism, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders of amino-acid metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 457 | 216 | 237 |
| Only index persons | 323 | 153 | 170 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.69 | 61.68 | 55.77 |
| Only index persons | 59.92 | 63.72 | 56.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 38 | 18 | 20 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 58.17 | 60.49 | 56.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint E4_AMINONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMINONAS | 1.813 [1.19, 2.77] | 0.006 |
| Birth year | 0.997 [0.99, 1.01] | 0.458 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 158 females with E4_AMINONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMINONAS | 3.184 [1.91, 5.31] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 174 males with E4_AMINONAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_AMINONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.178% | 0.628% |
| 5 | 1.062% | 3.808% |
| 10 | 2.809% | 9.333% |
| 15 | 5.638% | 17.533% |
| 20 | 9.606% | 28.165% |
Relationships between endpoints
↥Index endpoint: E4_AMINONAS – Disorder of amino-acid metabolism, other/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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