No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
78346 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
3356 |
6. Filter based on genotype QC (FinnGen only) |
3228 |
Control definitions (FinnGen only)
Control conditions
not I9_IHD
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF6v3
Similar endpoints
↥List of similar endpoints to
Familial hypercholesterolemia, with ischemic heart disease
based on the number of shared cases.
Similar with more cases:
- Familial hypercholesterolemia
- Pure hypercholesterolaemia
- Disorders of lipoprotein metabolism and other lipidaemias
- Metabolic disorders
- Ischaemic heart disease, wide definition
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 26704 | 11042 | 15581 |
| Only index persons | 25221 | 10477 | 14744 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.39 | 0.32 | 0.44 |
| Only index persons | 0.49 | 0.39 | 0.56 |
| Median age at first event (years) | |||
| Whole population | 70.10 | 74.13 | 67.25 |
| Only index persons | 70.07 | 74.09 | 67.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3228 | 1059 | 2169 |
| Unadjusted period prevalence (%) | 0.87 | 0.42 | 1.09 |
| Median age at first event (years) | 66.71 | 68.14 | 66.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_FH_IHD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FH_IHD | 1.385 [1.26, 1.52] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.385 |
During the follow-up period (1.1.1998 — 31.12.2019), 3789 out of 10026 females with E4_FH_IHD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FH_IHD | 1.505 [1.37, 1.66] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5058 out of 14273 males with E4_FH_IHD died.
Mortality risk
Mortality risk for people of age
years, who have E4_FH_IHD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.343% |
| 5 | 0.773% | 1.518% |
| 10 | 2.047% | 3.828% |
| 15 | 3.951% | 6.822% |
| 20 | 7.167% | 11.645% |
Relationships between endpoints
↥Index endpoint: E4_FH_IHD – Familial hypercholesterolemia, with ischemic heart disease
GWS hits: 14
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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