This is a non-core endpoint: only basic statistics are computed.
Disorders of glycoprotein metabolism
E4_GLYCOPROT
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
40 |
4. Check minimum number of eventsNone |
40 |
5. Include endpoints |
40 |
6. Filter based on genotype QC (FinnGen only) |
36 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E70-E90
Name in latin
Perturbationes metabolismi glycoproteinorum
Similar endpoints
↥List of similar endpoints to
Disorders of glycoprotein metabolism
based on the number of shared cases.
Similar with more cases:
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 490 | 243 | 246 |
| Only index persons | 390 | 191 | 199 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 39.76 | 40.27 | 39.07 |
| Only index persons | 38.47 | 38.07 | 38.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 36 | 21 | 15 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 52.05 | 52.52 | 51.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint E4_GLYCOPROT and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GLYCOPROT | 5.737 [3.32, 9.92] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 195 males with E4_GLYCOPROT died.
Mortality risk
Mortality risk for people of age
years, who have E4_GLYCOPROT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.985% |
| 5 | No data | 5.653% |
| 10 | No data | 14.629% |
| 15 | No data | 26.381% |
| 20 | No data | 40.026% |
Relationships between endpoints
↥Index endpoint: E4_GLYCOPROT – Disorders of glycoprotein metabolism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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