metabolic disease: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
94 |
4. Check minimum number of eventsNone |
94 |
5. Include endpointsNone |
94 |
6. Filter based on genotype QC (FinnGen only) |
87 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Metabolic disorder, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Other metabolic disorders
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1049 | 516 | 527 |
| Only index persons | 686 | 348 | 338 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 19.12 | 21.80 | 16.02 |
| Only index persons | 38.81 | 39.57 | 38.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 87 | 46 | 41 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 53.08 | 54.54 | 51.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_METABONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_METABONAS | 3.691 [2.35, 5.8] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.251 |
During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 330 females with E4_METABONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_METABONAS | 4.79 [3.22, 7.12] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 316 males with E4_METABONAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_METABONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.407% | 0.844% |
| 5 | 2.113% | 5.355% |
| 10 | 5.119% | 12.316% |
| 15 | 10.336% | 21.695% |
| 20 | 17.406% | 33.78% |
Relationships between endpoints
↥Index endpoint: E4_METABONAS – Metabolic disorder, other/unspecified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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