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Emotionally unstable personality disorder

DOID EFO Endpoint Browser PheWeb

F5_EMOPER

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F60.3
  • Hospital discharge: ICD-9 — 3018D
  • Hospital discharge: ICD-8 — 3013
  • Cause of death: ICD-10 — F60.3
  • Cause of death: ICD-9 — 3018D
  • Cause of death: ICD-8 — 3013

2 out of 7 registries used, show all original rules.

5230

4. Check minimum number of events

None

5230

5. Include endpoints

None

5230

6. Filter based on genotype QC (FinnGen only)

5000

Control definitions (FinnGen only)

Control exclude F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F60
Name in latin Personalitas (emotionaliter) instabilis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 42432 28098 14023
Only index persons 38133 26529 11604
Unadjusted period prevalence (%)
Whole population 0.66 0.80 0.39
Only index persons 0.81 0.98 0.44
Median age at first event (years)
Whole population 29.63 28.52 31.78
Only index persons 29.05 28.09 31.24

-FinnGen-

Key figures

All Female Male
Number of individuals 5000 3821 1179
Unadjusted period prevalence (%) 1.29 1.50 0.59
Median age at first event (years) 30.17 29.20 33.32

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_EMOPER and mortality.

Females

Parameter HR [95% CI] p-value
F5_EMOPER 4.721 [4.21, 5.3] < 0.001
Birth year 0.997 [0.99, 1.01] 0.453

During the follow-up period (1.1.1998 — 31.12.2019), 1385 out of 20533 females with F5_EMOPER died.

Males

Parameter HR [95% CI] p-value
F5_EMOPER 5.121 [4.64, 5.66] < 0.001
Birth year 0.99 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 1395 out of 8016 males with F5_EMOPER died.

Mortality risk

Mortality risk for people of age

years, who have F5_EMOPER.

N-year risk Females Males
1 0.528% 1.007%
5 3.402% 6.785%
10 7.431% 15.11%
15 13.632% 26.88%
20 23.43% 43.11%

Relationships between endpoints

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Index endpoint: F5_EMOPER – Emotionally unstable personality disorder

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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