autonomic nervous system disease: A disease involving the autonomic nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
693 |
4. Check minimum number of eventsNone |
693 |
5. Include endpoints |
712 |
6. Filter based on genotype QC (FinnGen only) |
696 |
Control definitions (FinnGen only)
Control exclude
G6_OTHNEU
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G90-G99
Name in latin
Morbositates systematis nervosi autonomici
Similar endpoints
↥List of similar endpoints to
Autonomic disorders
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6006 | 2906 | 3053 |
| Only index persons | 5139 | 2553 | 2586 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.09 |
| Only index persons | 0.10 | 0.09 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 56.80 | 57.86 | 55.60 |
| Only index persons | 55.36 | 56.45 | 54.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 696 | 371 | 325 |
| Unadjusted period prevalence (%) | 0.15 | 0.15 | 0.16 |
| Median age at first event (years) | 56.24 | 55.39 | 57.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_AUTONOM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_AUTONOM | 2.775 [2.37, 3.25] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.162 |
During the follow-up period (1.1.1998 — 31.12.2019), 671 out of 2348 females with G6_AUTONOM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_AUTONOM | 2.517 [2.17, 2.92] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 798 out of 2520 males with G6_AUTONOM died.
Mortality risk
Mortality risk for people of age
years, who have G6_AUTONOM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.269% | 0.529% |
| 5 | 1.548% | 2.991% |
| 10 | 3.906% | 7.184% |
| 15 | 7.323% | 13.304% |
| 20 | 12.638% | 22.103% |
Relationships between endpoints
↥Index endpoint: G6_AUTONOM – Autonomic disorders
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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