brachial plexus neuropathy: Diseases of the cervical (and first thoracic) roots, nerve trunks, cords, and peripheral nerve components of the BRACHIAL PLEXUS. Clinical manifestations include regional pain, PARESTHESIA; MUSCLE WEAKNESS, and decreased sensation (HYPESTHESIA) in the upper extremity. These disorders may be associated with trauma (including BIRTH INJURIES); THORACIC OUTLET SYNDROME; NEOPLASMS; NEURITIS; RADIOTHERAPY; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp1351-2)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3561 |
4. Check minimum number of eventsNone |
3561 |
5. Include endpointsNone |
3561 |
6. Filter based on genotype QC (FinnGen only) |
3446 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G54
Name in latin
Morbositates plexus brachialis
Similar endpoints
↥List of similar endpoints to
Brachial plexus disorders
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 23987 | 15535 | 8362 |
| Only index persons | 23334 | 15301 | 8033 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.37 | 0.44 | 0.23 |
| Only index persons | 0.47 | 0.56 | 0.31 |
| Median age at first event (years) | |||
| Whole population | 43.67 | 43.16 | 44.62 |
| Only index persons | 43.52 | 43.09 | 44.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3446 | 2493 | 953 |
| Unadjusted period prevalence (%) | 0.84 | 0.98 | 0.48 |
| Median age at first event (years) | 45.13 | 43.73 | 48.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_BRACHPLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_BRACHPLE | 1.046 [0.91, 1.21] | 0.533 |
| Birth year | 0.996 [0.99, 1.0] | 0.384 |
During the follow-up period (1.1.1998 — 31.12.2019), 483 out of 13189 females with G6_BRACHPLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_BRACHPLE | 1.098 [0.98, 1.24] | 0.121 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 572 out of 6908 males with G6_BRACHPLE died.
Mortality risk
Mortality risk for people of age
years, who have G6_BRACHPLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.145% | 0.166% |
| 5 | 0.691% | 1.219% |
| 10 | 1.728% | 3.33% |
| 15 | 3.132% | 6.468% |
| 20 | 5.488% | 10.939% |
Relationships between endpoints
↥Index endpoint: G6_BRACHPLE – Brachial plexus disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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