peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
223 |
4. Check minimum number of eventsNone |
223 |
5. Include endpointsNone |
223 |
6. Filter based on genotype QC (FinnGen only) |
211 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G54
Name in latin
Morbositates radicum nervorum cervicalium non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Cervical root disorders
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1967 | 895 | 1060 |
| Only index persons | 1814 | 845 | 969 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 53.07 | 52.51 | 53.45 |
| Only index persons | 52.39 | 51.91 | 52.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 211 | 112 | 99 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | 53.63 | 51.99 | 55.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_CERVROOT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CERVROOT | 1.156 [0.87, 1.54] | 0.324 |
| Birth year | 0.996 [0.99, 1.0] | 0.362 |
During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 666 females with G6_CERVROOT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CERVROOT | 1.369 [1.08, 1.73] | 0.009 |
| Birth year | 0.985 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 773 males with G6_CERVROOT died.
Mortality risk
Mortality risk for people of age
years, who have G6_CERVROOT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.23% |
| 5 | 0.607% | 1.299% |
| 10 | 1.623% | 3.363% |
| 15 | 3.355% | 6.757% |
| 20 | 5.694% | 11.257% |
Relationships between endpoints
↥Index endpoint: G6_CERVROOT – Cervical root disorders
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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