No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
112145 |
4. Check minimum number of eventsNone |
112145 |
5. Include endpoints |
115921 |
6. Filter based on genotype QC (FinnGen only) |
111849 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Episodal and paroxysmal disorders
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 923677 | 467653 | 450061 |
| Only index persons | 834285 | 431531 | 402754 |
| Unadjusted period prevalence (%) | |||
| Whole population | 12.95 | 13.39 | 12.57 |
| Only index persons | 15.63 | 15.86 | 15.37 |
| Median age at first event (years) | |||
| Whole population | 52.62 | 52.55 | 52.67 |
| Only index persons | 51.82 | 51.63 | 52.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 111849 | 60613 | 51236 |
| Unadjusted period prevalence (%) | 24.69 | 23.81 | 25.73 |
| Median age at first event (years) | 53.60 | 51.17 | 56.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_EPIPAROX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_EPIPAROX | 1.449 [1.34, 1.57] | < 0.001 |
| Birth year | 0.992 [0.99, 1.0] | 0.044 |
During the follow-up period (1.1.1998 — 31.12.2019), 62646 out of 361208 females with G6_EPIPAROX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_EPIPAROX | 1.57 [1.44, 1.71] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 67429 out of 331774 males with G6_EPIPAROX died.
Mortality risk
Mortality risk for people of age
years, who have G6_EPIPAROX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.098% | 0.197% |
| 5 | 0.654% | 1.161% |
| 10 | 1.779% | 3.214% |
| 15 | 3.239% | 6.121% |
| 20 | 5.685% | 10.154% |
Relationships between endpoints
↥Index endpoint: G6_EPIPAROX – Episodal and paroxysmal disorders
GWS hits: 13
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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