peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
103 |
4. Check minimum number of eventsNone |
103 |
5. Include endpointsNone |
103 |
6. Filter based on genotype QC (FinnGen only) |
100 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G54
Name in latin
Morbositates plexus lumbosacralis
Similar endpoints
↥List of similar endpoints to
Lumbosacral plexus disorders
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 903 | 486 | 412 |
| Only index persons | 807 | 435 | 372 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.12 | 55.89 | 56.21 |
| Only index persons | 54.07 | 54.21 | 53.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 100 | 59 | 41 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 54.69 | 52.91 | 57.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_LSPLEX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_LSPLEX | 1.681 [1.22, 2.31] | 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.403 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 391 females with G6_LSPLEX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_LSPLEX | 1.151 [0.85, 1.56] | 0.365 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 342 males with G6_LSPLEX died.
Mortality risk
Mortality risk for people of age
years, who have G6_LSPLEX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.198% |
| 5 | 1.097% | 1.208% |
| 10 | 2.546% | 2.93% |
| 15 | 4.988% | 5.664% |
| 20 | 8.872% | 9.948% |
Relationships between endpoints
↥Index endpoint: G6_LSPLEX – Lumbosacral plexus disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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