No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4231 |
4. Check minimum number of eventsNone |
4231 |
5. Include endpoints |
4313 |
6. Filter based on genotype QC (FinnGen only) |
4163 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Diseases of the myoneural junction and muscle
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 42435 | 19202 | 22973 |
| Only index persons | 37440 | 17431 | 20009 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.60 | 0.55 | 0.64 |
| Only index persons | 0.71 | 0.64 | 0.76 |
| Median age at first event (years) | |||
| Whole population | 64.79 | 68.78 | 61.48 |
| Only index persons | 65.24 | 69.09 | 61.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4163 | 1895 | 2268 |
| Unadjusted period prevalence (%) | 0.96 | 0.74 | 1.14 |
| Median age at first event (years) | 60.58 | 58.28 | 62.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_MYONEU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MYONEU | 2.179 [1.94, 2.45] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 5630 out of 15018 females with G6_MYONEU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MYONEU | 2.996 [2.64, 3.4] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 7312 out of 17909 males with G6_MYONEU died.
Mortality risk
Mortality risk for people of age
years, who have G6_MYONEU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.158% | 0.431% |
| 5 | 1.15% | 3.041% |
| 10 | 2.834% | 7.753% |
| 15 | 5.241% | 15.018% |
| 20 | 9.066% | 25.303% |
Relationships between endpoints
↥Index endpoint: G6_MYONEU – Diseases of the myoneural junction and muscle
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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