nervous system disease: A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2257 |
4. Check minimum number of eventsNone |
2257 |
5. Include endpointsNone |
2257 |
6. Filter based on genotype QC (FinnGen only) |
2166 |
Control definitions (FinnGen only)
Control exclude
G6_OTHNEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other disorders of nervous system
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13637 | 6281 | 7307 |
| Only index persons | 12774 | 5937 | 6837 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.18 | 0.20 |
| Only index persons | 0.24 | 0.22 | 0.26 |
| Median age at first event (years) | |||
| Whole population | 58.90 | 59.38 | 58.44 |
| Only index persons | 58.38 | 58.76 | 58.05 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2166 | 1079 | 1087 |
| Unadjusted period prevalence (%) | 0.49 | 0.42 | 0.55 |
| Median age at first event (years) | 58.94 | 57.20 | 60.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_NEUROOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_NEUROOTH | 1.537 [1.37, 1.72] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.136 |
During the follow-up period (1.1.1998 — 31.12.2019), 1028 out of 5356 females with G6_NEUROOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_NEUROOTH | 1.566 [1.4, 1.75] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1427 out of 6181 males with G6_NEUROOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_NEUROOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.305% |
| 5 | 0.884% | 1.664% |
| 10 | 2.071% | 4.471% |
| 15 | 4.006% | 8.346% |
| 20 | 6.955% | 13.924% |
Relationships between endpoints
↥Index endpoint: G6_NEUROOTH – Other disorders of nervous system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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