peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
83 |
4. Check minimum number of eventsNone |
83 |
5. Include endpointsNone |
83 |
6. Filter based on genotype QC (FinnGen only) |
83 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Phantom limb syndrome
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 726 | 302 | 414 |
| Only index persons | 586 | 241 | 345 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.02 | 56.33 | 55.54 |
| Only index persons | 53.45 | 53.67 | 53.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 83 | 36 | 47 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 55.47 | 50.45 | 59.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_PHANTOM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PHANTOM | 2.961 [1.92, 4.57] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.056 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 261 females with G6_PHANTOM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PHANTOM | 2.061 [1.55, 2.74] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 119 out of 361 males with G6_PHANTOM died.
Mortality risk
Mortality risk for people of age
years, who have G6_PHANTOM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.282% | 0.327% |
| 5 | 1.348% | 2.281% |
| 10 | 3.262% | 5.933% |
| 15 | 6.514% | 10.869% |
| 20 | 12.15% | 17.885% |
Relationships between endpoints
↥Index endpoint: G6_PHANTOM – Phantom limb syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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