gout: A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
309 |
4. Check minimum number of eventsNone |
309 |
5. Include endpointsNone |
309 |
6. Filter based on genotype QC (FinnGen only) |
300 |
Control definitions (FinnGen only)
Control exclude
GOUT
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M10
Name in latin
Arthritis urica ex insufficientia renali
Gout due to impairment of renal function
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1900 | 646 | 1244 |
| Only index persons | 1736 | 586 | 1150 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.02 | 0.03 |
| Only index persons | 0.04 | 0.02 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 73.96 | 77.27 | 72.23 |
| Only index persons | 73.66 | 76.82 | 72.05 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 300 | 77 | 223 |
| Unadjusted period prevalence (%) | 0.09 | 0.03 | 0.11 |
| Median age at first event (years) | 70.22 | 72.35 | 69.49 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint GOUT_KIDNEY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GOUT_KIDNEY | 3.249 [2.27, 4.66] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 519 females with GOUT_KIDNEY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GOUT_KIDNEY | 3.409 [2.41, 4.82] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 471 out of 1000 males with GOUT_KIDNEY died.
Mortality risk
Mortality risk for people of age
years, who have GOUT_KIDNEY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.325% | 0.617% |
| 5 | 1.813% | 4.031% |
| 10 | 4.542% | 9.412% |
| 15 | 8.29% | 17.3% |
| 20 | 14.068% | 28.218% |
Relationships between endpoints
↥Index endpoint: GOUT_KIDNEY – Gout due to impairment of renal function
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data