No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
576 |
4. Check minimum number of eventsNone |
576 |
5. Include endpointsNone |
576 |
6. Filter based on genotype QC (FinnGen only) |
550 |
Control definitions (FinnGen only)
Control exclude
H7_LENS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H27
Name in latin
Aphakia
Aphakia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10286 | 5262 | 4814 |
| Only index persons | 5128 | 2468 | 2660 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.15 | 0.13 |
| Only index persons | 0.10 | 0.09 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 63.75 | 67.32 | 59.82 |
| Only index persons | 53.87 | 59.58 | 48.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 550 | 200 | 350 |
| Unadjusted period prevalence (%) | 0.14 | 0.08 | 0.18 |
| Median age at first event (years) | 55.56 | 54.30 | 56.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_APHAKIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_APHAKIA | 1.166 [1.01, 1.34] | 0.033 |
| Birth year | 0.994 [0.99, 1.0] | 0.218 |
During the follow-up period (1.1.1998 — 31.12.2019), 474 out of 1272 females with H7_APHAKIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_APHAKIA | 1.201 [1.03, 1.4] | 0.021 |
| Birth year | 0.985 [0.97, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 451 out of 1466 males with H7_APHAKIA died.
Mortality risk
Mortality risk for people of age
years, who have H7_APHAKIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.206% |
| 5 | 0.591% | 1.283% |
| 10 | 1.564% | 3.269% |
| 15 | 2.999% | 6.2% |
| 20 | 5.598% | 10.411% |
Relationships between endpoints
↥Index endpoint: H7_APHAKIA – Aphakia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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