glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
100 |
4. Check minimum number of eventsNone |
100 |
5. Include endpointsNone |
100 |
6. Filter based on genotype QC (FinnGen only) |
99 |
Control definitions (FinnGen only)
Control exclude
H7_GLAUCOMA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H40
Name in latin
Glaucoma ex usu medicamenti
Similar endpoints
↥List of similar endpoints to
Glaucoma secondary to drugs
based on the number of shared cases.
Similar with more cases:
- Glaucoma
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 667 | 340 | 320 |
| Only index persons | 593 | 307 | 286 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 54.35 | 54.38 | 54.37 |
| Only index persons | 52.80 | 52.63 | 52.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 99 | 48 | 51 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 53.45 | 51.13 | 55.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_GLAUCSECDRUG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCSECDRUG | 1.913 [1.39, 2.64] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.14 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 267 females with H7_GLAUCSECDRUG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_GLAUCSECDRUG | 1.552 [1.14, 2.11] | 0.005 |
| Birth year | 0.988 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 245 males with H7_GLAUCSECDRUG died.
Mortality risk
Mortality risk for people of age
years, who have H7_GLAUCSECDRUG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.161% | 0.328% |
| 5 | 1.124% | 1.904% |
| 10 | 2.803% | 4.702% |
| 15 | 5.382% | 8.75% |
| 20 | 9.14% | 14.514% |
Relationships between endpoints
↥Index endpoint: H7_GLAUCSECDRUG – Glaucoma secondary to drugs
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data