No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
2116 |
6. Filter based on genotype QC (FinnGen only) |
2049 |
Control definitions (FinnGen only)
Control exclude
I9_DOAAC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Arterial embolism and thrombosis
based on the number of shared cases.
Similar with more cases:
- Diseases of arteries, arterioles and capillaries (FINNGEN)
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 27721 | 13004 | 14204 |
| Only index persons | 16261 | 7930 | 8331 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.39 | 0.37 | 0.40 |
| Only index persons | 0.31 | 0.29 | 0.32 |
| Median age at first event (years) | |||
| Whole population | 72.83 | 77.35 | 68.83 |
| Only index persons | 71.96 | 76.51 | 67.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2049 | 752 | 1297 |
| Unadjusted period prevalence (%) | 0.52 | 0.30 | 0.65 |
| Median age at first event (years) | 68.07 | 66.85 | 68.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_ARTEMBTHR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_ARTEMBTHR | 2.635 [2.31, 3.0] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.398 |
During the follow-up period (1.1.1998 — 31.12.2019), 4270 out of 6960 females with I9_ARTEMBTHR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_ARTEMBTHR | 2.675 [2.36, 3.03] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 4120 out of 7568 males with I9_ARTEMBTHR died.
Mortality risk
Mortality risk for people of age
years, who have I9_ARTEMBTHR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.261% | 0.373% |
| 5 | 1.47% | 2.864% |
| 10 | 3.929% | 6.946% |
| 15 | 7.427% | 12.852% |
| 20 | 13.09% | 21.619% |
Relationships between endpoints
↥Index endpoint: I9_ARTEMBTHR – Arterial embolism and thrombosis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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