≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Other diseases of arteries and capillaries

DOID EFO Endpoint Browser PheWeb

I9_ARTOTH

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I77, I78, I79*
  • Hospital discharge: ICD-9 — 447|448
  • Hospital discharge: ICD-8 — 447|448
  • Cause of death: ICD-10 — I77, I78, I79*
  • Cause of death: ICD-9 — 447|448
  • Cause of death: ICD-8 — 447|448

2 out of 7 registries used, show all original rules.

3340

4. Check minimum number of events

None

3340

5. Include endpoints

None

3340

6. Filter based on genotype QC (FinnGen only)

3208

Control definitions (FinnGen only)

Control exclude I9_DOAAC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 28289 14969 13017
Only index persons 22501 12429 10072
Unadjusted period prevalence (%)
Whole population 0.40 0.43 0.36
Only index persons 0.42 0.46 0.38
Median age at first event (years)
Whole population 60.56 59.08 62.07
Only index persons 57.76 55.97 59.96

-FinnGen-

Key figures

All Female Male
Number of individuals 3208 1632 1576
Unadjusted period prevalence (%) 0.71 0.64 0.79
Median age at first event (years) 58.69 53.35 64.22

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint I9_ARTOTH and mortality.

Females

Parameter HR [95% CI] p-value
I9_ARTOTH 1.811 [1.67, 1.97] < 0.001
Birth year 0.995 [0.99, 1.0] 0.265

During the follow-up period (1.1.1998 — 31.12.2019), 3383 out of 11102 females with I9_ARTOTH died.

Males

Parameter HR [95% CI] p-value
I9_ARTOTH 2.237 [2.03, 2.46] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 4263 out of 9618 males with I9_ARTOTH died.

Mortality risk

Mortality risk for people of age

years, who have I9_ARTOTH.

N-year risk Females Males
1 0.149% 0.447%
5 1.036% 2.45%
10 2.787% 5.705%
15 5.466% 11.13%
20 9.508% 18.017%

Relationships between endpoints

↥

Index endpoint: I9_ARTOTH – Other diseases of arteries and capillaries

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data