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Non-rheumatic valve diseases

DOID EFO Endpoint Browser PheWeb

I9_NONRHEVALV

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I34, I35, I36, I37
  • Hospital discharge: ICD-9 — 424
  • Hospital discharge: ICD-8 — 39[4-6]|424
  • Hospital discharge: excluded ICD-8 — 4249|3940|3950|3960|3970
  • Cause of death: ICD-10 — I34, I35, I36, I37
  • Cause of death: ICD-9 — 424
  • Cause of death: ICD-8 — 39[4-6]|424
  • Cause of death: excluded ICD-8 — 4249|3940|3950|3960|3970

2 out of 7 registries used, show all original rules.

26137

4. Check minimum number of events

None

26137

5. Include endpoints

None

26137

6. Filter based on genotype QC (FinnGen only)

25200

Control definitions (FinnGen only)

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 215676 107164 106544
Only index persons 175595 87966 87629
Unadjusted period prevalence (%)
Whole population 3.01 3.07 2.98
Only index persons 3.29 3.23 3.35
Median age at first event (years)
Whole population 71.82 74.38 69.26
Only index persons 71.28 73.70 68.86

-FinnGen-

Key figures

All Female Male
Number of individuals 25200 10703 14497
Unadjusted period prevalence (%) 5.97 4.20 7.28
Median age at first event (years) 69.04 69.30 68.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_NONRHEVALV and mortality.

Females

Parameter HR [95% CI] p-value
I9_NONRHEVALV 1.736 [1.59, 1.89] < 0.001
Birth year 0.991 [0.98, 1.0] 0.055

During the follow-up period (1.1.1998 — 31.12.2019), 31028 out of 80329 females with I9_NONRHEVALV died.

Males

Parameter HR [95% CI] p-value
I9_NONRHEVALV 1.699 [1.55, 1.87] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 28903 out of 78811 males with I9_NONRHEVALV died.

Mortality risk

Mortality risk for people of age

years, who have I9_NONRHEVALV.

N-year risk Females Males
1 0.163% 0.268%
5 0.874% 1.582%
10 2.138% 3.94%
15 4.021% 7.365%
20 6.991% 12.656%

Relationships between endpoints

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Index endpoint: I9_NONRHEVALV – Non-rheumatic valve diseases

GWS hits: 10

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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