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Other or ill-defined heart diseases

DOID EFO Endpoint Browser PheWeb

I9_OTHILLHEART

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I51, I52*
  • Hospital discharge: ICD-9 — 429
  • Hospital discharge: ICD-8 — 42899|42999
  • Cause of death: ICD-10 — I51, I52*
  • Cause of death: ICD-9 — 429
  • Cause of death: ICD-8 — 42899|42999

2 out of 7 registries used, show all original rules.

2003

4. Check minimum number of events

None

2003

5. Include endpoints

None

2003

6. Filter based on genotype QC (FinnGen only)

1932

Control definitions (FinnGen only)

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 33677 12205 20779
Only index persons 17579 6000 11579
Unadjusted period prevalence (%)
Whole population 0.50 0.35 0.58
Only index persons 0.37 0.22 0.44
Median age at first event (years)
Whole population 58.86 65.01 55.08
Only index persons 51.92 58.39 48.57

-FinnGen-

Key figures

All Female Male
Number of individuals 1932 698 1234
Unadjusted period prevalence (%) 0.49 0.27 0.62
Median age at first event (years) 54.80 54.28 55.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_OTHILLHEART and mortality.

Females

Parameter HR [95% CI] p-value
I9_OTHILLHEART 2.38 [2.04, 2.77] < 0.001
Birth year 0.991 [0.98, 1.0] 0.038

During the follow-up period (1.1.1998 — 31.12.2019), 1023 out of 3349 females with I9_OTHILLHEART died.

Males

Parameter HR [95% CI] p-value
I9_OTHILLHEART 2.371 [2.05, 2.75] < 0.001
Birth year 0.989 [0.98, 1.0] 0.039

During the follow-up period (1.1.1998 — 31.12.2019), 1115 out of 6178 males with I9_OTHILLHEART died.

Mortality risk

Mortality risk for people of age

years, who have I9_OTHILLHEART.

N-year risk Females Males
1 0.213% 0.452%
5 1.362% 2.737%
10 3.343% 6.988%
15 5.763% 13.198%
20 10.061% 21.709%

Relationships between endpoints

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Index endpoint: I9_OTHILLHEART – Other or ill-defined heart diseases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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