≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Paroxysmal tachycardia

EFO MESH Endpoint Browser PheWeb

I9_PAROXTAC

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I47
  • Hospital discharge: ICD-9 — 427[0-2]
  • Hospital discharge: ICD-8 — 4275
  • Cause of death: ICD-10 — I47
  • Cause of death: ICD-9 — 427[0-2]
  • Cause of death: ICD-8 — 4275

2 out of 7 registries used, show all original rules.

12003

4. Check minimum number of events

None

12003

5. Include endpoints

None

12003

6. Filter based on genotype QC (FinnGen only)

11595

Control definitions (FinnGen only)

Control exclude FG_CVD

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I30-I52
Name in latin Tachycardia paroxysmalis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 96448 49738 45864
Only index persons 81802 43904 37898
Unadjusted period prevalence (%)
Whole population 1.35 1.42 1.28
Only index persons 1.54 1.61 1.45
Median age at first event (years)
Whole population 58.85 57.96 59.65
Only index persons 56.37 55.49 57.38

-FinnGen-

Key figures

All Female Male
Number of individuals 11595 6096 5499
Unadjusted period prevalence (%) 2.57 2.39 2.76
Median age at first event (years) 57.31 53.45 61.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint I9_PAROXTAC and mortality.

Females

Parameter HR [95% CI] p-value
I9_PAROXTAC 1.339 [1.23, 1.45] < 0.001
Birth year 0.999 [0.99, 1.01] 0.826

During the follow-up period (1.1.1998 — 31.12.2019), 7240 out of 38181 females with I9_PAROXTAC died.

Males

Parameter HR [95% CI] p-value
I9_PAROXTAC 1.693 [1.55, 1.85] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 9389 out of 33842 males with I9_PAROXTAC died.

Mortality risk

Mortality risk for people of age

years, who have I9_PAROXTAC.

N-year risk Females Males
1 0.131% 0.213%
5 0.813% 1.667%
10 2.13% 4.212%
15 3.928% 7.794%
20 7.038% 12.567%

Relationships between endpoints

↥

Index endpoint: I9_PAROXTAC – Paroxysmal tachycardia

GWS hits: 9

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data