cholelithiasis: The presence of calculi in the gallbladder.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
46324 |
4. Check minimum number of eventsNone |
46324 |
5. Include endpointsNone |
46324 |
6. Filter based on genotype QC (FinnGen only) |
44582 |
Control definitions (FinnGen only)
Control exclude
K11_GALLBILPANC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K80-K87
Name in latin
Cholelithiasis
Similar endpoints
↥List of similar endpoints to
Cholelithiasis
based on the number of shared cases.
Similar with more cases:
- Cholelithiasis, broad definition with cholecystitis
- Disorders of gallbladder, biliary tract and pancreas
- Gastrointestinal diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 441478 | 299595 | 137690 |
| Only index persons | 355443 | 249330 | 106113 |
| Unadjusted period prevalence (%) | |||
| Whole population | 7.06 | 8.58 | 3.85 |
| Only index persons | 7.64 | 9.17 | 4.05 |
| Median age at first event (years) | |||
| Whole population | 56.10 | 53.78 | 60.99 |
| Only index persons | 53.27 | 50.99 | 58.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 44582 | 30240 | 14342 |
| Unadjusted period prevalence (%) | 10.37 | 11.88 | 7.20 |
| Median age at first event (years) | 52.42 | 48.64 | 60.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_CHOLELITH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CHOLELITH | 1.167 [1.08, 1.26] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.043 |
During the follow-up period (1.1.1998 — 31.12.2019), 28224 out of 151232 females with K11_CHOLELITH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CHOLELITH | 1.225 [1.13, 1.33] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 24016 out of 79683 males with K11_CHOLELITH died.
Mortality risk
Mortality risk for people of age
years, who have K11_CHOLELITH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.062% | 0.21% |
| 5 | 0.62% | 1.34% |
| 10 | 1.498% | 3.252% |
| 15 | 2.71% | 6.219% |
| 20 | 5.083% | 10.309% |
Relationships between endpoints
↥Index endpoint: K11_CHOLELITH – Cholelithiasis
GWS hits: 84
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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