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Gingivitis and periodontal diseases

EFO Endpoint Browser PheWeb

K11_GINGIVITIS_PERIODONTAL

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — K05
  • Hospital discharge: ICD-10 — K05
  • Hospital discharge: ICD-9 — 523
  • Hospital discharge: ICD-8 — 523
  • Cause of death: ICD-10 — K05
  • Cause of death: ICD-9 — 523
  • Cause of death: ICD-8 — 523

3 out of 7 registries used, show all original rules.

124055

4. Check minimum number of events

None

124055

5. Include endpoints

None

124055

6. Filter based on genotype QC (FinnGen only)

118404

Control definitions (FinnGen only)

Control exclude K11_ORAL

Extra metadata

First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1126339 605054 512819
Only index persons 1095088 594583 500505
Unadjusted period prevalence (%)
Whole population 15.90 17.33 14.33
Only index persons 20.60 21.86 19.11
Median age at first event (years)
Whole population 41.64 41.70 41.70
Only index persons 42.17 42.15 42.20

-FinnGen-

Key figures

All Female Male
Number of individuals 118404 73319 45085
Unadjusted period prevalence (%) 26.45 28.80 22.64
Median age at first event (years) 53.80 50.84 58.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_GINGIVITIS_PERIODONTAL and mortality.

Females

Parameter HR [95% CI] p-value
K11_GINGIVITIS_PERIODONTAL 1.243 [1.04, 1.49] 0.018
Birth year 0.992 [0.98, 1.0] 0.047

During the follow-up period (1.1.1998 — 31.12.2019), 15525 out of 477374 females with K11_GINGIVITIS_PERIODONTAL died.

Males

Parameter HR [95% CI] p-value
K11_GINGIVITIS_PERIODONTAL 1.331 [1.13, 1.57] < 0.001
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 20783 out of 397801 males with K11_GINGIVITIS_PERIODONTAL died.

Mortality risk

Mortality risk for people of age

years, who have K11_GINGIVITIS_PERIODONTAL.

N-year risk Females Males
1 0.099% 0.2%
5 0.564% 1.247%
10 1.527% 3.201%
15 2.858% 6.3%
20 5.14% 10.533%

Relationships between endpoints

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Index endpoint: K11_GINGIVITIS_PERIODONTAL – Gingivitis and periodontal diseases

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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