No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
257848 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
40021 |
6. Filter based on genotype QC (FinnGen only) |
38157 |
Control definitions (FinnGen only)
Control exclude
K11_PARODON_OPER
Control conditions
K11_DENTAL_OPER
Extra metadata
First used in FinnGen datafreeze
DF7
Parodontitis or/and operation codes
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 274134 | 137809 | 134146 |
| Only index persons | 270355 | 137119 | 133236 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.84 | 3.95 | 3.75 |
| Only index persons | 5.06 | 5.04 | 5.09 |
| Median age at first event (years) | |||
| Whole population | 59.81 | 60.84 | 59.11 |
| Only index persons | 59.99 | 60.85 | 59.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 38157 | 20435 | 17722 |
| Unadjusted period prevalence (%) | 8.43 | 8.03 | 8.90 |
| Median age at first event (years) | 62.82 | 61.67 | 64.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_PARODON_OPER_DENTAL_OPER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PARODON_OPER_DENTAL_OPER | 1.034 [0.87, 1.22] | 0.697 |
| Birth year | 0.996 [0.99, 1.0] | 0.258 |
During the follow-up period (1.1.1998 — 31.12.2019), 4955 out of 105318 females with K11_PARODON_OPER_DENTAL_OPER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PARODON_OPER_DENTAL_OPER | 1.132 [0.96, 1.34] | 0.148 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 7302 out of 102277 males with K11_PARODON_OPER_DENTAL_OPER died.
Mortality risk
Mortality risk for people of age
years, who have K11_PARODON_OPER_DENTAL_OPER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.079% | 0.189% |
| 5 | 0.652% | 1.256% |
| 10 | 1.651% | 3.119% |
| 15 | 3.11% | 5.877% |
| 20 | 5.245% | 9.77% |
Relationships between endpoints
↥Index endpoint: K11_PARODON_OPER_DENTAL_OPER – Parodontitis or/and operation codes
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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