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Mental retardation

Endpoint Browser PheWeb

KRA_PSY_MENTALRET_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F70-F79
  • Hospital discharge: ICD-9 — 31[7-9]
  • Hospital discharge: ICD-8 — 31[1-5]
  • Cause of death: ICD-10 — F70-F79
  • Cause of death: ICD-9 — 31[7-9]
  • Cause of death: ICD-8 — 31[1-5]

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 42454 18381 23958
Only index persons 34472 15015 19457
Unadjusted period prevalence (%)
Whole population 0.61 0.53 0.67
Only index persons 0.66 0.55 0.74
Median age at first event (years)
Whole population 15.58 17.76 13.76
Only index persons 15.95 17.81 14.51

-FinnGen-

Key figures

All Female Male
Number of individuals 1329 660 669
Unadjusted period prevalence (%) 0.30 0.26 0.34
Median age at first event (years) 23.41 24.65 22.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint KRA_PSY_MENTALRET_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_MENTALRET_EXMORE 4.664 [4.03, 5.39] < 0.001
Birth year 0.995 [0.99, 1.0] 0.254

During the follow-up period (1.1.1998 — 31.12.2019), 1080 out of 9154 females with KRA_PSY_MENTALRET_EXMORE died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_MENTALRET_EXMORE 3.916 [3.41, 4.49] < 0.001
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1270 out of 12728 males with KRA_PSY_MENTALRET_EXMORE died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_MENTALRET_EXMORE.

N-year risk Females Males
1 0.398% 0.654%
5 2.615% 4.192%
10 7.048% 10.306%
15 12.211% 18.579%
20 21.058% 30.023%

Relationships between endpoints

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Index endpoint: KRA_PSY_MENTALRET_EXMORE – Mental retardation

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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