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Tic disorders

DOID EFO Endpoint Browser PheWeb

KRA_PSY_TIC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F95
  • Hospital discharge: ICD-9 — 3072
  • Hospital discharge: ICD-8 — 30620
  • Cause of death: ICD-10 — F95
  • Cause of death: ICD-9 — 3072
  • Cause of death: ICD-8 — 30620

2 out of 7 registries used, show all original rules.

448

4. Check minimum number of events

None

448

5. Include endpoints

None

448

6. Filter based on genotype QC (FinnGen only)

420

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 F90-F98
Name in latin Perturbationes ticiformes

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12184 3427 8742
Only index persons 9944 2898 7046
Unadjusted period prevalence (%)
Whole population 0.20 0.10 0.24
Only index persons 0.22 0.11 0.27
Median age at first event (years)
Whole population 9.93 10.84 9.52
Only index persons 10.81 12.11 10.28

-FinnGen-

Key figures

All Female Male
Number of individuals 420 216 204
Unadjusted period prevalence (%) 0.09 0.08 0.10
Median age at first event (years) 14.61 17.26 11.79

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint KRA_PSY_TIC and mortality.

Females

Parameter HR [95% CI] p-value
KRA_PSY_TIC 1.34 [0.94, 1.92] 0.111
Birth year 0.994 [0.99, 1.0] 0.182

During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 2389 females with KRA_PSY_TIC died.

Males

Parameter HR [95% CI] p-value
KRA_PSY_TIC 1.569 [1.19, 2.07] 0.001
Birth year 0.99 [0.98, 1.0] 0.03

During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 6900 males with KRA_PSY_TIC died.

Mortality risk

Mortality risk for people of age

years, who have KRA_PSY_TIC.

N-year risk Females Males
1 0.136% 0.294%
5 0.77% 1.889%
10 1.82% 4.912%
15 3.571% 9.327%
20 6.152% 15.684%

Relationships between endpoints

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Index endpoint: KRA_PSY_TIC – Tic disorders

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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