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Other arthrosis

DOID EFO Endpoint Browser PheWeb

M13_ARTHROSIS_OTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M18, M19
  • Hospital discharge: ICD-9 — 7151|7152
  • Hospital discharge: ICD-8 — 713
  • Hospital discharge: excluded ICD-9 — 7151L|7151E|7151F|7152L|7152E|7152F
  • Hospital discharge: excluded ICD-8 — 7130[0-1]|71303|7131
  • Cause of death: ICD-10 — M18, M19
  • Cause of death: ICD-9 — 7151|7152
  • Cause of death: ICD-8 — 713
  • Cause of death: excluded ICD-9 — 7151L|7151E|7151F|7152L|7152E|7152F
  • Cause of death: excluded ICD-8 — 7130[0-1]|71303

2 out of 7 registries used, show all original rules.

26835

4. Check minimum number of events

None

26835

5. Include endpoints

None

26835

6. Filter based on genotype QC (FinnGen only)

26066

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 186677 107786 78002
Only index persons 171938 100268 71670
Unadjusted period prevalence (%)
Whole population 2.70 3.09 2.18
Only index persons 3.29 3.69 2.74
Median age at first event (years)
Whole population 58.55 60.08 56.43
Only index persons 58.00 59.53 55.87

-FinnGen-

Key figures

All Female Male
Number of individuals 26066 15816 10250
Unadjusted period prevalence (%) 5.79 6.21 5.15
Median age at first event (years) 58.25 58.45 57.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_ARTHROSIS_OTH and mortality.

Females

Parameter HR [95% CI] p-value
M13_ARTHROSIS_OTH 1.035 [0.95, 1.13] 0.421
Birth year 0.993 [0.98, 1.0] 0.082

During the follow-up period (1.1.1998 — 31.12.2019), 11783 out of 82556 females with M13_ARTHROSIS_OTH died.

Males

Parameter HR [95% CI] p-value
M13_ARTHROSIS_OTH 0.957 [0.87, 1.05] 0.341
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 8305 out of 59820 males with M13_ARTHROSIS_OTH died.

Mortality risk

Mortality risk for people of age

years, who have M13_ARTHROSIS_OTH.

N-year risk Females Males
1 0.105% 0.148%
5 0.558% 1.064%
10 1.424% 2.666%
15 2.559% 5.055%
20 4.422% 8.727%

Relationships between endpoints

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Index endpoint: M13_ARTHROSIS_OTH – Other arthrosis

GWS hits: 9

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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