No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3423 |
4. Check minimum number of eventsNone |
3423 |
5. Include endpointsNone |
3423 |
6. Filter based on genotype QC (FinnGen only) |
3315 |
Control definitions (FinnGen only)
Control exclude
M13_OSTEOCHONDRO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M80-M85
Name in latin
Perturbationes continuitatis ossis
Similar endpoints
↥List of similar endpoints to
Disorders of continuity of bone
based on the number of shared cases.
Similar with more cases:
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 29414 | 15578 | 13687 |
| Only index persons | 27495 | 14661 | 12834 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.42 | 0.45 | 0.38 |
| Only index persons | 0.52 | 0.54 | 0.49 |
| Median age at first event (years) | |||
| Whole population | 48.36 | 55.08 | 40.68 |
| Only index persons | 47.21 | 54.33 | 39.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3315 | 2122 | 1193 |
| Unadjusted period prevalence (%) | 0.75 | 0.83 | 0.60 |
| Median age at first event (years) | 53.40 | 54.19 | 52.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_BONECONTINUITY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONECONTINUITY | 2.042 [1.83, 2.28] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.147 |
During the follow-up period (1.1.1998 — 31.12.2019), 2291 out of 12198 females with M13_BONECONTINUITY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONECONTINUITY | 2.355 [2.08, 2.67] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1893 out of 11005 males with M13_BONECONTINUITY died.
Mortality risk
Mortality risk for people of age
years, who have M13_BONECONTINUITY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.186% | 0.42% |
| 5 | 1.185% | 2.56% |
| 10 | 2.745% | 6.277% |
| 15 | 5.261% | 10.91% |
| 20 | 9.063% | 17.796% |
Relationships between endpoints
↥Index endpoint: M13_BONECONTINUITY – Disorders of continuity of bone
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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