No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
887 |
4. Check minimum number of eventsNone |
887 |
5. Include endpointsNone |
887 |
6. Filter based on genotype QC (FinnGen only) |
858 |
Control definitions (FinnGen only)
Control exclude
M13_OSTEOCHONDRO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M80-M85
Name in latin
Aliae perturbationes densitatis et structurae ossium
Similar endpoints
↥List of similar endpoints to
Other disorders of bone density and structure
based on the number of shared cases.
Similar with more cases:
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8060 | 4419 | 3617 |
| Only index persons | 7643 | 4236 | 3407 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.10 |
| Only index persons | 0.14 | 0.16 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 39.96 | 45.13 | 33.56 |
| Only index persons | 39.69 | 44.77 | 33.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 858 | 547 | 311 |
| Unadjusted period prevalence (%) | 0.19 | 0.21 | 0.16 |
| Median age at first event (years) | 45.27 | 45.18 | 45.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_BONEDENSOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDENSOTH | 1.323 [1.12, 1.56] | < 0.001 |
| Birth year | 0.995 [0.99, 1.01] | 0.332 |
During the follow-up period (1.1.1998 — 31.12.2019), 397 out of 3559 females with M13_BONEDENSOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDENSOTH | 1.259 [1.08, 1.47] | 0.004 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 307 out of 2959 males with M13_BONEDENSOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_BONEDENSOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.162% | 0.24% |
| 5 | 0.766% | 1.641% |
| 10 | 1.882% | 3.791% |
| 15 | 3.928% | 7.102% |
| 20 | 6.893% | 11.974% |
Relationships between endpoints
↥Index endpoint: M13_BONEDENSOTH – Other disorders of bone density and structure
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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