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Internal derangement of knee

DOID EFO Endpoint Browser PheWeb

M13_KNEEDERANGEMENTS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M23
  • Hospital discharge: ICD-9 — 717
  • Hospital discharge: ICD-8 — 72410
  • Hospital discharge: excluded ICD-9 — M23[0-3]
  • Hospital discharge: excluded ICD-8 — 717[0-5]|7177
  • Cause of death: ICD-10 — M23
  • Cause of death: ICD-9 — 717
  • Cause of death: ICD-8 — 72410
  • Cause of death: excluded ICD-9 — M23[0-3]
  • Cause of death: excluded ICD-8 — 717[0-5]|7177

2 out of 7 registries used, show all original rules.

44051

4. Check minimum number of events

None

44051

5. Include endpoints

None

44051

6. Filter based on genotype QC (FinnGen only)

42717

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M20-M25
Name in latin Vitia interna genus

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 355021 162591 190859
Only index persons 333480 155481 177999
Unadjusted period prevalence (%)
Whole population 5.01 4.66 5.33
Only index persons 6.29 5.72 6.79
Median age at first event (years)
Whole population 46.36 49.85 43.38
Only index persons 45.98 49.52 42.88

-FinnGen-

Key figures

All Female Male
Number of individuals 42717 21872 20845
Unadjusted period prevalence (%) 9.51 8.59 10.47
Median age at first event (years) 47.65 48.54 46.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_KNEEDERANGEMENTS and mortality.

Females

Parameter HR [95% CI] p-value
M13_KNEEDERANGEMENTS 0.74 [0.68, 0.8] < 0.001
Birth year 0.996 [0.99, 1.0] 0.282

During the follow-up period (1.1.1998 — 31.12.2019), 8803 out of 113271 females with M13_KNEEDERANGEMENTS died.

Males

Parameter HR [95% CI] p-value
M13_KNEEDERANGEMENTS 0.705 [0.65, 0.76] < 0.001
Birth year 0.986 [0.98, 1.0] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 10185 out of 119085 males with M13_KNEEDERANGEMENTS died.

Mortality risk

Mortality risk for people of age

years, who have M13_KNEEDERANGEMENTS.

N-year risk Females Males
1 0.071% 0.114%
5 0.477% 0.766%
10 1.21% 1.933%
15 2.253% 3.764%
20 3.92% 6.474%

Relationships between endpoints

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Index endpoint: M13_KNEEDERANGEMENTS – Internal derangement of knee

GWS hits: 13

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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