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Other osteochondropathies

DOID EFO Endpoint Browser PheWeb

M13_OSTEOCHONDROPATHY

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M93
  • Hospital discharge: ICD-9 — 7322|732[7-9]
  • Hospital discharge: ICD-8 — 722
  • Hospital discharge: excluded ICD-8 — 72209|7222[8-9]
  • Cause of death: ICD-10 — M93
  • Cause of death: ICD-9 — 7322|732[7-9]
  • Cause of death: ICD-8 — 722
  • Cause of death: excluded ICD-8 — 72209|7222[8-9]

2 out of 7 registries used, show all original rules.

2636

4. Check minimum number of events

None

2636

5. Include endpoints

None

2636

6. Filter based on genotype QC (FinnGen only)

2547

Control definitions (FinnGen only)

Control exclude M13_OTHERBONE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M91-M94
Name in latin Aliae osteochondropathiae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 26291 10313 15871
Only index persons 24429 9765 14664
Unadjusted period prevalence (%)
Whole population 0.38 0.30 0.44
Only index persons 0.48 0.36 0.56
Median age at first event (years)
Whole population 22.35 23.72 21.33
Only index persons 21.66 22.98 20.78

-FinnGen-

Key figures

All Female Male
Number of individuals 2547 1262 1285
Unadjusted period prevalence (%) 0.57 0.50 0.65
Median age at first event (years) 26.04 24.79 27.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_OSTEOCHONDROPATHY and mortality.

Females

Parameter HR [95% CI] p-value
M13_OSTEOCHONDROPATHY 1.062 [0.88, 1.28] 0.522
Birth year 0.993 [0.98, 1.0] 0.122

During the follow-up period (1.1.1998 — 31.12.2019), 155 out of 4483 females with M13_OSTEOCHONDROPATHY died.

Males

Parameter HR [95% CI] p-value
M13_OSTEOCHONDROPATHY 0.818 [0.7, 0.96] 0.011
Birth year 0.989 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 211 out of 6001 males with M13_OSTEOCHONDROPATHY died.

Mortality risk

Mortality risk for people of age

years, who have M13_OSTEOCHONDROPATHY.

N-year risk Females Males
1 0.076% 0.175%
5 0.637% 0.997%
10 1.393% 2.652%
15 2.861% 4.997%
20 5.251% 8.44%

Relationships between endpoints

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Index endpoint: M13_OSTEOCHONDROPATHY – Other osteochondropathies

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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