arthritis: An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1321 |
4. Check minimum number of eventsNone |
1321 |
5. Include endpointsNone |
1321 |
6. Filter based on genotype QC (FinnGen only) |
1282 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M13
Name in latin
Polyarthritis NAS
Similar endpoints
↥List of similar endpoints to
Polyarthritis, unspecified
based on the number of shared cases.
Similar with more cases:
- Other arthritis (FG)
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9797 | 5674 | 4039 |
| Only index persons | 8477 | 5001 | 3476 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.16 | 0.11 |
| Only index persons | 0.16 | 0.18 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 53.37 | 52.56 | 54.28 |
| Only index persons | 51.86 | 50.97 | 53.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1282 | 767 | 515 |
| Unadjusted period prevalence (%) | 0.28 | 0.30 | 0.26 |
| Median age at first event (years) | 51.17 | 47.94 | 55.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_POLYARTHRITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLYARTHRITIS | 1.314 [1.18, 1.47] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.072 |
During the follow-up period (1.1.1998 — 31.12.2019), 742 out of 3877 females with M13_POLYARTHRITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLYARTHRITIS | 1.534 [1.36, 1.73] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 723 out of 2820 males with M13_POLYARTHRITIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_POLYARTHRITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.092% | 0.25% |
| 5 | 0.742% | 1.823% |
| 10 | 1.726% | 4.371% |
| 15 | 3.488% | 8.113% |
| 20 | 6.128% | 13.419% |
Relationships between endpoints
↥Index endpoint: M13_POLYARTHRITIS – Polyarthritis, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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