psoriatic arthritis: Joint inflammation associated with psoriasis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4050 |
4. Check minimum number of eventsNone |
4050 |
5. Include endpointsNone |
4050 |
6. Filter based on genotype QC (FinnGen only) |
3897 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Psoriatic arthropathies
based on the number of shared cases.
Similar with more cases:
- Psoriatic and enteropathic arthropathies
- Polyarthropathies
- Autoimmune diseases related-to ILD
- Finngen Rheumatological endpoints
- Arthropathies
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22720 | 11238 | 11370 |
| Only index persons | 21177 | 10670 | 10507 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.32 | 0.32 | 0.32 |
| Only index persons | 0.40 | 0.39 | 0.40 |
| Median age at first event (years) | |||
| Whole population | 50.47 | 51.66 | 49.27 |
| Only index persons | 50.09 | 51.30 | 48.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3897 | 2136 | 1761 |
| Unadjusted period prevalence (%) | 0.86 | 0.84 | 0.88 |
| Median age at first event (years) | 50.81 | 50.78 | 50.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_PSORIARTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PSORIARTH | 1.301 [1.16, 1.46] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 766 out of 8776 females with M13_PSORIARTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PSORIARTH | 1.194 [1.08, 1.32] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1118 out of 8548 males with M13_PSORIARTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_PSORIARTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.118% | 0.209% |
| 5 | 0.688% | 1.217% |
| 10 | 1.762% | 3.225% |
| 15 | 3.127% | 6.311% |
| 20 | 5.428% | 10.426% |
Relationships between endpoints
↥Index endpoint: M13_PSORIARTH – Psoriatic arthropathies
GWS hits: 15
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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