musculoskeletal system disease: A disease involving the musculoskeletal system. [database_cross_reference: MONDO:DesignPattern]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
125341 |
4. Check minimum number of eventsNone |
125341 |
5. Include endpoints |
132019 |
6. Filter based on genotype QC (FinnGen only) |
127203 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Soft tissue disorders
based on the number of shared cases.
Similar with more cases:
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1074859 | 583578 | 485541 |
| Only index persons | 997467 | 552201 | 445266 |
| Unadjusted period prevalence (%) | |||
| Whole population | 15.24 | 16.72 | 13.57 |
| Only index persons | 18.83 | 20.30 | 17.00 |
| Median age at first event (years) | |||
| Whole population | 50.48 | 50.99 | 49.89 |
| Only index persons | 50.17 | 50.72 | 49.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 127203 | 75569 | 51634 |
| Unadjusted period prevalence (%) | 28.16 | 29.68 | 25.93 |
| Median age at first event (years) | 52.04 | 50.33 | 54.54 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SOFTTISSUE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SOFTTISSUE | 1.115 [1.02, 1.21] | 0.012 |
| Birth year | 0.993 [0.99, 1.0] | 0.061 |
During the follow-up period (1.1.1998 — 31.12.2019), 50612 out of 440323 females with M13_SOFTTISSUE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SOFTTISSUE | 1.073 [0.99, 1.16] | 0.092 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 49386 out of 359115 males with M13_SOFTTISSUE died.
Mortality risk
Mortality risk for people of age
years, who have M13_SOFTTISSUE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.109% | 0.165% |
| 5 | 0.587% | 1.02% |
| 10 | 1.4% | 2.429% |
| 15 | 2.561% | 4.774% |
| 20 | 4.471% | 8.127% |
Relationships between endpoints
↥Index endpoint: M13_SOFTTISSUE – Soft tissue disorders
GWS hits: 15
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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