breast disease: A disease involving the breast.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
5946 |
4. Check minimum number of eventsNone |
5946 |
5. Include endpointsNone |
5946 |
6. Filter based on genotype QC (FinnGen only) |
5727 |
Control definitions (FinnGen only)
Control exclude
N14_BREAST
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N60-N64
Name in latin
Nodulus mammae non specificatus
Unspecified lump in breast
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 47503 | 47503 | - |
| Only index persons | 44685 | 44685 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.36 | 1.36 | - |
| Only index persons | 1.64 | 1.64 | - |
| Median age at first event (years) | |||
| Whole population | - | 50.39 | - |
| Only index persons | - | 50.01 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5727 | 5727 | - |
| Unadjusted period prevalence (%) | 2.25 | 2.25 | - |
| Median age at first event (years) | 49.18 | 49.18 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_LUMPNASBREAST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_LUMPNASBREAST | 1.221 [1.13, 1.32] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.181 |
During the follow-up period (1.1.1998 — 31.12.2019), 5884 out of 38029 females with N14_LUMPNASBREAST died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_LUMPNASBREAST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.105% | No data |
| 5 | 0.663% | No data |
| 10 | 1.729% | No data |
| 15 | 3.388% | No data |
| 20 | 6.044% | No data |
Relationships between endpoints
↥Index endpoint: N14_LUMPNASBREAST – Unspecified lump in breast
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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