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Irregular menses

Endpoint Browser PheWeb

N14_MENSIRREG

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N91, N92.1, N92.5, N92.6
  • Hospital discharge: ICD-9 — 6264A
  • Hospital discharge: ICD-8 — 6265
  • Cause of death: ICD-10 — N91, N92.1, N92.5, N92.6
  • Cause of death: ICD-9 — 6264A
  • Cause of death: ICD-8 — 6265

2 out of 7 registries used, show all original rules.

22757

4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

21784

Control definitions (FinnGen only)

Control exclude E4_PCOS_CONCORTIUM

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF6
Parent code in ICD-10 N80-N98
Name in latin Menstruatio abundans, frequens et irregularis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 156837 156837 -
Only index persons 152088 152088 -
Unadjusted period prevalence (%)
Whole population 4.49 4.49 -
Only index persons 5.59 5.59 -
Median age at first event (years)
Whole population - 40.30 -
Only index persons - 40.09 -

-FinnGen-

Key figures

All Female Male
Number of individuals 21784 21784 -
Unadjusted period prevalence (%) 8.56 8.56 -
Median age at first event (years) 40.74 40.74 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_MENSIRREG and mortality.

Females

Parameter HR [95% CI] p-value
N14_MENSIRREG 1.224 [1.12, 1.34] < 0.001
Birth year 0.997 [0.99, 1.0] 0.456

During the follow-up period (1.1.1998 — 31.12.2019), 3729 out of 113292 females with N14_MENSIRREG died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_MENSIRREG.

N-year risk Females Males
1 0.107% No data
5 0.721% No data
10 1.952% No data
15 3.719% No data
20 6.491% No data

Relationships between endpoints

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Index endpoint: N14_MENSIRREG – Irregular menses

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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