No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1986 |
4. Check minimum number of eventsNone |
1986 |
5. Include endpointsNone |
1986 |
6. Filter based on genotype QC (FinnGen only) |
1899 |
Control definitions (FinnGen only)
Control exclude
N14_URINOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N30-N39
Name in latin
Strictura urethrae
Urethral stricture
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17409 | 1938 | 15254 |
| Only index persons | 14226 | 1650 | 12576 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.38 | 0.06 | 0.43 |
| Only index persons | 0.43 | 0.06 | 0.48 |
| Median age at first event (years) | |||
| Whole population | 63.48 | 60.09 | 63.84 |
| Only index persons | 61.21 | 57.86 | 61.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1899 | 193 | 1706 |
| Unadjusted period prevalence (%) | 0.78 | 0.08 | 0.86 |
| Median age at first event (years) | 64.69 | 54.68 | 65.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_URETHRALSTRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_URETHRALSTRICT | 1.538 [1.32, 1.79] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.103 |
During the follow-up period (1.1.1998 — 31.12.2019), 443 out of 1429 females with N14_URETHRALSTRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_URETHRALSTRICT | 1.203 [1.09, 1.32] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 3256 out of 10911 males with N14_URETHRALSTRICT died.
Mortality risk
Mortality risk for people of age
years, who have N14_URETHRALSTRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.152% | 0.209% |
| 5 | 0.831% | 1.408% |
| 10 | 2.067% | 3.446% |
| 15 | 3.993% | 6.582% |
| 20 | 7.039% | 11.296% |
Relationships between endpoints
↥Index endpoint: N14_URETHRALSTRICT – Urethral stricture
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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