No definition available.
Drug-induced osteoporosis with pathological fracture
EFO MESH Endpoint Browser PheWeb
OSTPOPATFRACTURE
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
442 |
4. Check minimum number of eventsNone |
442 |
5. Include endpointsNone |
442 |
6. Filter based on genotype QC (FinnGen only) |
434 |
Control definitions (FinnGen only)
Control exclude
OSTEOPOROSIS_FRACTURE_FG
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M80
Name in latin
Osteoporosis e medicamento cum fractura pathologica
Similar endpoints
↥List of similar endpoints to
Drug-induced osteoporosis with pathological fracture
based on the number of shared cases.
Similar with more cases:
- Osteoporosis with pathological fracture (FG)
- Osteoporosis
- Osteopathies and chondropathies
- Finngen Rheumatological endpoints
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2573 | 1758 | 796 |
| Only index persons | 2250 | 1568 | 682 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 70.33 | 71.59 | 67.62 |
| Only index persons | 70.23 | 71.36 | 67.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 434 | 306 | 128 |
| Unadjusted period prevalence (%) | 0.10 | 0.12 | 0.06 |
| Median age at first event (years) | 68.15 | 68.19 | 68.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint OSTPOPATFRACTURE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| OSTPOPATFRACTURE | 2.879 [2.39, 3.46] | < 0.001 |
| Birth year | 0.996 [0.99, 1.01] | 0.421 |
During the follow-up period (1.1.1998 — 31.12.2019), 572 out of 1455 females with OSTPOPATFRACTURE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| OSTPOPATFRACTURE | 4.177 [3.06, 5.7] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.09 |
During the follow-up period (1.1.1998 — 31.12.2019), 329 out of 649 males with OSTPOPATFRACTURE died.
Mortality risk
Mortality risk for people of age
years, who have OSTPOPATFRACTURE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.297% | 0.753% |
| 5 | 1.672% | 4.626% |
| 10 | 3.99% | 12.785% |
| 15 | 7.552% | 23.481% |
| 20 | 14.115% | 37.703% |
Relationships between endpoints
↥Index endpoint: OSTPOPATFRACTURE – Drug-induced osteoporosis with pathological fracture
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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