No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1732 |
4. Check minimum number of eventsNone |
1732 |
5. Include endpointsNone |
1732 |
6. Filter based on genotype QC (FinnGen only) |
1677 |
Control definitions (FinnGen only)
Control exclude
KNEE_ARTHROSIS
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M17
Name in latin
Alia gonarthrosis secundaria
Similar endpoints
↥List of similar endpoints to
Other secondary gonarthrosis
based on the number of shared cases.
Similar with more cases:
- Gonarthrosis
- Gonarthrosis [arthrosis of knee](FG)
- Arthrosis
- Finngen Rheumatological endpoints
- Artrosis, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13147 | 6589 | 6446 |
| Only index persons | 11182 | 5819 | 5363 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.19 | 0.18 |
| Only index persons | 0.21 | 0.21 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 56.46 | 59.11 | 53.59 |
| Only index persons | 54.68 | 57.72 | 51.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1677 | 892 | 785 |
| Unadjusted period prevalence (%) | 0.37 | 0.35 | 0.39 |
| Median age at first event (years) | 54.79 | 55.88 | 53.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint SCND_OTH_KNEEARTHROSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SCND_OTH_KNEEARTHROSIS | 1.12 [1.01, 1.25] | 0.038 |
| Birth year | 0.998 [0.99, 1.01] | 0.606 |
During the follow-up period (1.1.1998 — 31.12.2019), 700 out of 4019 females with SCND_OTH_KNEEARTHROSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SCND_OTH_KNEEARTHROSIS | 0.972 [0.87, 1.09] | 0.621 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 603 out of 3532 males with SCND_OTH_KNEEARTHROSIS died.
Mortality risk
Mortality risk for people of age
years, who have SCND_OTH_KNEEARTHROSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.11% | 0.173% |
| 5 | 0.715% | 1.05% |
| 10 | 1.69% | 2.695% |
| 15 | 3.183% | 5.245% |
| 20 | 6.244% | 9.207% |
Relationships between endpoints
↥Index endpoint: SCND_OTH_KNEEARTHROSIS – Other secondary gonarthrosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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